Animated DNA origami

November 24, 2010 § Leave a comment

This video animates the process of getting a circular DNA molecule (from M13 filamentous bacteriophage) to fold up into a rectangular sheet, using DNA “staples”.  The staples bind to two segments of the circular DNA that may be far apart when you look at the DNA sequence; the two parts of the staple force these segments to come together, imposing two-dimensional shape on the structure.  I like the way the DNA is portrayed as a dinosaur spine…

Whoever put it on YouTube doesn’t specify where the work came from, but I think it’s from this paper (PDF).  (Maune et al. 2010, Self-assembly of carbon nanotubes into two-dimensional geometries using DNA origami templates. Nat Nanotechnol. 5 61-6. PMID: 19898497).

Local practitioners of similar approaches include William Shih and Peng Yin.

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