Theory Lunch this week

February 24, 2011 § Leave a comment

Gabriel Kreiman will talk on “Computations in neuronal circuits: learning rules at “bottom-up” and “top-down connections”” this Friday, 25 Feb 2011

Seeing, hearing, feeling, planning and even proving mathematical theorems is the result of computations in the ~10(11) neurons in our brains. Understanding the function of cerebral cortex is arguably one of the greatest scientific challenges of our time and will require the interplay of empirical work and rigorous theoretical models. In this talk I will give a succinct overview of theoretical approaches aimed towards understanding the biophysics of computations in cortex and focus on one particular problem that we are working on. Briefly, connections in cortex can be divided into “bottom-up” and “top-down”. What type of synaptic plasticity rules at cortical top-down synapses could be compatible with the development of a stable and diverse distribution of top-down synaptic strengths? We compare two possible plasticity rules with different temporal characteristics and ask which could be a viable mechanism for learning at top-down synapses. Specifically, we compare the effects of classical spike-timing dependent plasticity (classical STDP) versus a temporally reversed version (reverse STDP). We show that a bias towards potentiation can lead to the development of strong excitatory feedback loops, which cause activity to explode but that this explosion can be prevented by a bias towards depression. Using analytical methods and simulations, we determine that only reverse STDP allows top-down connection weights to attain an unchanging distribution. Altogether, we conclude that depression-biased reverse STDP is required for the development of unchanging, diverse top-down connections.

Theory Lunch schedule here.

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )


Connecting to %s

What’s this?

You are currently reading Theory Lunch this week at It Takes 30.


%d bloggers like this: