Theory lunch this week

April 27, 2011 § Leave a comment

The homeostatic regulation of the unfolded protein response

29 Apr 2011

Hana El-Samad
Departments of Biochemistry and Biophysics
University of California, San Francisco,
and the California Institute for Quantitative Biosciences

Abstract

The unfolded protein response (UPR) is an intracellular signaling pathway that maintains proper function of the endoplasmic reticulum (ER), counteracting variable stresses that impair folding of proteins. In this capacity, the UPR is at the center of many normal physiological responses and pathologies. In this study, we quantitatively interrogate the homeostatic capacity of the UPR. Moving between a predictive computational model and quantitative dynamic measurements, we establish how the dynamic behavior of the UPR is fine tuned, especially with regard to important performance criteria such as sensitivity and shutoff kinetics. In this quest, we describe new computational approaches that allow for the rigorous analysis of underdetermined models of biological dynamics.

TL schedule here.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

What’s this?

You are currently reading Theory lunch this week at It Takes 30.

meta

%d bloggers like this: