Theory lunch TODAY

May 13, 2011 § Leave a comment

I almost forgot to post this — sorry! This week’s theory lunch speaker, is Leonid Mirny. His title is:

How do cells pack their DNA?

TODAY, May 13, noon-1.30, WAB 563 (HMS).

Abstract

How are two meters of human DNA folded inside a cell nucleus? Packing and processing of DNA by the cells pose several intriguing problems for polymer physics. Recently developed experimental methods of chromosome conformational capture provided a comprehensive view at DNA organization inside the cell. I will summarize several physical characteristics of higher-order chromatin structure revealed by these experiments. Next, I will introduce a polymer model of the “fractal globule” and suggest why this dense, highly organized, and unknotted conformation is an attractive model for chromatin architecture. I will discuss connections between high-order chromatin architecture, gene expression and chromosomal abnormalities in cancer.

TL schedule here.

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