Post-doc positions, MSKCC

October 13, 2011 § Leave a comment

Postdoctoral Openings: Molecular Mechanisms of Eukaryotic Gene Expression Regulation

We are seeking highly motivated individuals for postdoctoral positions in the Structural Biology Program of the Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, NYC, USA. The lab develops cutting-edge techniques aimed at gaining a detailed, mechanistic understanding of the regulation of gene expression in eukaryotes. Major emphasis is placed on development of novel single-molecule detection and manipulation instrumentation (e.g. Nature, doi:10.1038/nature09163 (2010)) that pushes the envelope in sensitivity as well as in spatial and temporal resolution. Our group’s current focus is on real-time, in-vivo super-resolution optical nanoscopy and on high-precision combined single-molecule fluorescence/optical force- and torque-spectroscopy. Successful applicants will fully utilize the superb technological capabilities in the lab and apply the tools developed to outstanding biological questions. Example ongoing projects include:

i) in vitro single-molecule transcription initiation studies with a fully reconstituted RNA Polymerase II system

ii) Biochemistry of mRNA transcription activation in the nucleus of single living cells

iii) Transcriptional regulation of gene expression in the developing embryo

Applicants must possess a Ph.D. degree in Physics, Biophysics, Chemistry or a relevant field. Demonstrated ability to approach biological problems in a quantitative manner is essential. Experience with optics instrumentation is preferred. Individuals with additional working knowledge of basic biochemistry, cell biology and yeast, fly or mouse genetics techniques are strongly encouraged to apply. Please send a CV, names and contact information of three references and a short description of your scientific interests by email to Dr. Alexandros Pertsinidis (PertsinA AT

Memorial Sloan-Kettering Cancer Center is an equal opportunity employer with a strong commitment to enhancing the diversity of its faculty and staff. Women and applicants from diverse racial, ethnic and cultural backgrounds are encouraged to apply.

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