Theory Lunch this week

June 25, 2012 § Leave a comment

Dynamical bases of cellular heterogeneity

Jordi Garcia-Ojalvo
Department of Physics
Technical University of Catalonia, Spain

29 June 2012, 12-1.30 pm, WAB 563

Abstract
Cellular heterogeneity is frequently associated with the stochasticity of biochemical reactions within the cell. However, there are other mechanisms through which heterogeneous behavior can arise in cell populations. In these scenarios noise plays only a secondary role, being filtered by gene and protein circuits leading to a dynamical behavior that is unsynchronized across the population. In this talk I will discuss examples of these types of mechanisms in the particular case of embryonic stem cell pluripotency, which is known to be both strongly dynamical and heterogeneous. I will explore what we can learn from the observed heterogeneity in the levels of pluripotency factors, and from measurements of the correlated heterogeneity in pairs of such factors under different signaling scenarios. Within that context, I will present a theoretical model of pluripotency that reproduces these observations reasonably well, potentially leading us to a better understanding of the nature of pluripotency.

TL schedule here.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

What’s this?

You are currently reading Theory Lunch this week at It Takes 30.

meta

%d bloggers like this: